Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo.

@article{Kunkel1996DistinctPO,
  title={Distinct phenotype of E-selectin-deficient mice. E-selectin is required for slow leukocyte rolling in vivo.},
  author={Eric J. Kunkel and Klaus Ley},
  journal={Circulation research},
  year={1996},
  volume={79 6},
  pages={1196-204}
}
Leukocyte capture and rolling are mediated by calcium-dependent lectins expressed on most leukocytes (L-selectin) and the vascular endothelium (P- and E-selectin). To study the role of the selectins during inflammation, we have investigated leukocyte rolling in venules of tumor necrosis factor-alpha (TNF-alpha)-treated mouse cremaster muscles in wild-type mice and gene-targeted mice with homozygous deficiency for L-, P-, or E-selectin (L-/-, P-/-, or E-/-, respectively). TNF-alpha treatment… CONTINUE READING

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