Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual

  title={Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual},
  author={Pedro A. F. Galante and Raphael Bessa Parmigiani and Qi Zhao and Otavia L. Caballero and Jorge Estefano Santana de Souza and Fabio Navarro and Alexandra L. Gerber and Marisa F. Nicolas and Anna Christina de Matos Salim and Ana Paula Silva and Lee Edsall and Sylvie Devalle and Luiz Gonzaga Almeida and Zhen Ye and Samantha Kuan and Daniel Guariz Pinheiro and Israel Tojal and Renato G. Pedigoni and Rodrigo G. M. A. de Sousa and Thiago Y. K. Oliveira and Marcelo G. de Paula and Lucila Ohno-Machado and Ewen Kirkness and Samuel Levy and Wilson Ara{\'u}jo da Silva and Ana Tereza Ribeiro de Vasconcelos and Bing Ren and Marco A. Zago and Robert Strausberg and Andrew J. G. Simpson and Sandro J de Souza and Anamaria A. Camargo},
  booktitle={Nucleic acids research},
Although patterns of somatic alterations have been reported for tumor genomes, little is known on how they compare with alterations present in non-tumor genomes. A comparison of the two would be crucial to better characterize the genetic alterations driving tumorigenesis. We sequenced the genomes of a lymphoblastoid (HCC1954BL) and a breast tumor (HCC1954) cell line derived from the same patient and compared the somatic alterations present in both. The lymphoblastoid genome presents a… CONTINUE READING
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