Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity

@article{Silverman1988DistinctPO,
  title={Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity},
  author={Gregg J Silverman and Fernando Go{\~n}i and Juana Graciela Fernandez and Pojen P. Chen and Blas Frangione and Dennis Anthony Carson},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={168},
  pages={2361 - 2366}
}
Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding… CONTINUE READING