Corpus ID: 23457486

Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development.

  title={Distinct patterns of expression of MHC class I and beta 2-microglobulin transcripts at early stages of mouse development.},
  author={Leah Jaffe and Elizabeth J. Robertson and Elizabeth K. Bikoff},
  journal={Journal of immunology},
  volume={147 8},
The class I surface Ag recognized during tissue graft rejection are composed of a 40- to 45-kDa H chain and a 12-kDa L chain, beta 2-microglobulin (beta 2m). Regulation of MHC gene expression during early development is thought to play an essential role in maternal tolerance of the fetal allograft. Here we used in situ hybridization techniques to characterize the temporal and spatial pattern of expression of MHC class I mRNA in the developing mouse embryo. MHC class I transcripts were initially… Expand
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