Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors.

@article{Mitsiades2012DistinctPO,
  title={Distinct patterns of dysregulated expression of enzymes involved in androgen synthesis and metabolism in metastatic prostate cancer tumors.},
  author={Nicholas S Mitsiades and Clifford C. Sung and Nikolaus Schultz and Daniel Costin Danila and Bin He and Vijay Kumar Eedunuri and M. Fleisher and Chris Sander and Charles L Sawyers and Howard I. Scher},
  journal={Cancer research},
  year={2012},
  volume={72 23},
  pages={6142-52}
}
Androgen receptor (AR) signaling persists in castration-resistant prostate carcinomas (CRPC), because of several mechanisms that include increased AR expression and intratumoral androgen metabolism. We investigated the mechanisms underlying aberrant expression of transcripts involved in androgen metabolism in CRPC. We compared gene expression profiles and DNA copy number alteration (CNA) data from 29 normal prostate tissue samples, 127 primary prostate carcinomas (PCa), and 19 metastatic PCas… CONTINUE READING
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