Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists.

@article{Huang2009DistinctPO,
  title={Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists.},
  author={Haibin Huang and Gary R Ostroff and Chrono K. Lee and Jennifer P. Wang and Charles A. Specht and Stuart M Levitz},
  journal={Infection and immunity},
  year={2009},
  volume={77 5},
  pages={1774-81}
}
beta-Glucans derived from fungal cell walls have potential uses as immunomodulating agents and vaccine adjuvants. Yeast glucan particles (YGPs) are highly purified Saccharomyces cerevisiae cell walls composed of beta1,6-branched beta1,3-d-glucan and free of mannans. YGPs stimulated secretion of the proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha) in wild-type murine bone marrow-derived myeloid dendritic cells (BMDCs) but did not stimulate interleukin-12p70 (IL-12p70) production… CONTINUE READING

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