Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.

@article{Oliveira2004DistinctPO,
  title={Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status.},
  author={Carla Oliveira and Jantine L. Westra and Diego Arango and Miina Ollikainen and Enric Garcia i Domingo and Ana Ferreira and S{\'e}rgia Velho and Ren{\'e}e C. Niessen and Kristina Lagerstedt and Pia Alhopuro and Paivi Laiho and Isabel Veiga and Manuel R Teixeira and Marjolijn J. L. Ligtenberg and Jan H. Kleibeuker and Rolf H. Sijmons and John T.M. Plukker and Kohzoh Imai and Pedro Lage and Richard C Hamelin and Cristina Albuquerque and Sim{\'o} Schwartz and Annika Lindblom and P{\"a}ivi Peltomaki and Hiroyuki Yamamoto and Lauri A. Aaltonen and Raquel Seruca and Robert M. W. Hofstra},
  journal={Human molecular genetics},
  year={2004},
  volume={13 19},
  pages={
          2303-11
        }
}
In sporadic colorectal tumours the BRAFV600E is associated with microsatellite instability (MSI-H) and inversely associated to KRAS mutations. Tumours from hereditary non-polyposis colorectal cancer (HNPCC) patients carrying germline mutations in hMSH2 or hMLH1 do not show BRAFV600E, however no consistent data exist regarding KRAS mutation frequency and spectrum in HNPCC tumours. We investigated KRAS in 158 HNPCC tumours from patients with germline hMLH1, hMSH2 or hMSH6 mutations, 166 MSI-H and… CONTINUE READING

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