Distinct patterns of 1p and 19q alterations identify subtypes of human gliomas that have different prognoses.


We studied the status of chromosomes 1 and 19 in 363 astrocytic and oligodendroglial tumors. Whereas the predominant pattern of copy number abnormality was a concurrent loss of the entire 1p and 19q regions (total 1p/19q loss) among oligodendroglial tumors and partial deletions of 1p and/or 19q in astrocytic tumors, a subset of apparently astrocytic tumors… (More)
DOI: 10.1093/neuonc/nop075


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