Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.

@article{Umesako2007DistinctPO,
  title={Distinct pattern of allelic loss and inactivation of cadherin 1 and 5 genes in mammary carcinomas arising in p53(+/-) mice.},
  author={Seiichi Umesako and Sayoko Iiga and Masahiro Takahashi and Kae Imura and Nobuko Mori and Doo-Pyo Hong and Chang-Woo Song and Ohtsura Niwa and Masaaki Okumoto},
  journal={Journal of radiation research},
  year={2007},
  volume={48 2},
  pages={
          143-52
        }
}
p53 is one of the most frequently mutated genes in mammary carcinomas (MCs). To detect tumor suppressor genes cooperating with a hetero-deficient p53 gene in mammary carcinogenesis, we first examined allelotypes in MCs from (BALB/cHeA x MSM/Ms) F(1)- p53(+/-) and (BALB/cHeA x 129/SvEv) F(1)- p53(+/-) female mice, and then surveyed down-regulated genes in the allelic loss regions. Genome-wide screening at 42 loci identified frequent (more than 30%) loss of heterozygosity (LOH) on chromosomes 5… CONTINUE READING

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