Distinct pathological features of the gallyas- and tau-positive glia in the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.

@article{Oyanagi1997DistinctPF,
  title={Distinct pathological features of the gallyas- and tau-positive glia in the Parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam.},
  author={Kiyomitsu Oyanagi and Takao Makifuchi and Takashi Ohtoh and Kwang Ming Chen and D. Carleton Gajdusek and Thomas N. Chase},
  journal={Journal of neuropathology and experimental neurology},
  year={1997},
  volume={56 3},
  pages={308-16}
}
We examined 50 patients with parkinsonism-dementia complex of Guam (Guam PDC), 10 Guamanian patients with amyotrophic lateral sclerosis (ALS), 5 patients with combined PDC and ALS (PDC-ALS), and 20 non-PDC non-ALS Guamanians, who had been autopsied between 1979 and 1982, paying special attention to glial inclusions. Gallyas-positive and tau-immunopositive intracytoplasmic inclusions were observed in many of the glial cells, in addition to extensive neurofibrillary tangles (NFTs) in the brains… CONTINUE READING