Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia.

  title={Distinct overexpression of Fas ligand on T lymphocytes in aplastic anemia.},
  author={Wenxin Li and Jinxiang Fu and Fengming Wang and Gehua Yu and Yong Wang and Zhang Xueguang},
  journal={Cellular & molecular immunology},
  volume={1 2},
Increased expression of Fas by hematopoietic progenitors in aplastic anemia (AA) suggests that Fas/Fas ligand (FasL) system plays a key role in the formation of severe pancytopenia. To further confirm the above hypothesis, T cells from 8 patients with AA were systematically studied for their FasL's distribution pattern, releasing manner and proapoptotic activity, compared with normal resting T cells and artificially activated T cell blasts. The results demonstrated that AA T cells abnormally… CONTINUE READING
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Aplastic Anemia

  • RK Shadduck
  • eds. Williams Hematology (sixth edition). London…
  • 2001
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