Distinct orientation of the alloreactive monoclonal CD8 T cell activation program by three different peptide/MHC complexes.

@article{AuphanAnezin2006DistinctOO,
  title={Distinct orientation of the alloreactive monoclonal CD8 T cell activation program by three different peptide/MHC complexes.},
  author={Nathalie Auphan-Anezin and Catherine Mazza and Annick Guimezanes and Gregory A. Barrett-Wilt and F{\'e}lix A. Montero-Julian and Alain Roussel and Donald F. Hunt and Bernard Malissen and Anne-Marie Schmitt-Verhulst},
  journal={European journal of immunology},
  year={2006},
  volume={36 7},
  pages={1856-66}
}
We have characterized three different programs of activation for alloreactive CD8 T cells expressing the BM3.3 TCR, their elicitation depending on the characteristics of the stimulating peptide/MHC complex. The high-affinity interaction between the TCR and the K(b)-associated endogenous peptide pBM1 (INFDFNTI) induced a complete differentiation program into effector cells correlated with sustained ERK activation. The K(bm8) variant elicited a partial activation program with delayed T cell… CONTINUE READING

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