Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.

@article{Sogawa1984DistinctOO,
  title={Distinct organization of methylcholanthrene- and phenobarbital-inducible cytochrome P-450 genes in the rat.},
  author={Kazuhiro Sogawa and Osamu Gotoh and Kaname Kawajiri and Yoshiaki Fujii-Kuriyama},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1984},
  volume={81 16},
  pages={5066-70}
}
The complete nucleotide sequence of the methylcholanthrene-inducible cytochrome P-450c gene was determined by sequence analysis of cloned genomic DNA and the sequence, consisting of 524 amino acids, of the protein was deduced therefrom. The gene for the cytochrome was approximately 6.0 kilobases long and was split into seven exons. Comparison of the gene with that of the phenobarbital-inducible cytochrome P-450e showed that the gene structures for the two types of cytochrome P-450 differ… CONTINUE READING