Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site.

@article{Vincent2010DistinctOF,
  title={Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site.},
  author={Florence Vincent and Adam Round and Aline Reynaud and Christophe Bordi and Alain Filloux and Yves Bourne},
  journal={Environmental microbiology},
  year={2010},
  volume={12 6},
  pages={1775-86}
}
Bacterial two-component regulatory systems (TCSs) sense environmental stimuli to adapt the lifestyle of microbial populations. For many TCSs the stimulus is a ligand of unknown chemical nature. Pseudomonas aeruginosa utilizes the closely related RetS and LadS sensor kinases to switch between acute and chronic infections. These sensor proteins antagonistically mediate biofilm formation through communication with a central TCS, GacA/GacS. Recently, it was shown that RetS modulates the GacS sensor… CONTINUE READING
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