Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction.

@article{Hamdani2009DistinctME,
  title={Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction.},
  author={Nazha Hamdani and Walter Paulus and Loek van Heerebeek and Attila Borb{\'e}ly and Nicky M. Boontje and Marian J. Zuidwijk and Jean G.F. Bronzwaer and Warner S. Simonides and Hans W. M. Niessen and Ger J M Stienen and Jolanda van der Velden},
  journal={European heart journal},
  year={2009},
  volume={30 15},
  pages={1863-72}
}
AIMS Left ventricular (LV) myocardial structure and function differ in heart failure (HF) with normal (N) and reduced (R) LV ejection fraction (EF). This difference could underlie an unequal outcome of trials with beta-blockers in heart failure with normal LVEF (HFNEF) and heart failure with reduced LVEF (HFREF) with mixed results observed in HFNEF and positive results in HFREF. To investigate whether beta-blockers have distinct myocardial effects in HFNEF and HFREF, myocardial structure… CONTINUE READING