Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.

@article{Oudraogo2008DistinctMO,
  title={Distinct motifs of neuropeptide Y receptors differentially regulate trafficking and desensitization.},
  author={Moussa Ou{\'e}draogo and Sandra Lecat and Moulay Driss Rochdi and Muriel Hachet-Haas and Hans Matthes and Herv{\'e} Gicquiaux and Sophie Verrier and Mireille Gaire and Nicole M. Glasser and Yves M{\'e}ly and Kenneth Takeda and Michel Bouvier and J Galzi and Bernard Bucher},
  journal={Traffic},
  year={2008},
  volume={9 3},
  pages={305-24}
}
Activated human neuropeptide Y Y(1) receptors rapidly desensitize and internalize through clathrin-coated pits and recycle from early and recycling endosomes, unlike Y(2) receptors that neither internalize nor desensitize. To identify motifs implicated in Y(1) receptor desensitization and trafficking, mutants with varying C-terminal truncations or a substituted Y(2) C-terminus were constructed. Point mutations of key putative residues were made in a C-terminal conserved motif [phi-H-(S/T)-(E/D… CONTINUE READING

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