Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms

@article{Srlie2006DistinctMM,
  title={Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms},
  author={Th{\'e}rese S\orlie and Yulei Wang and Chunlin Xiao and Hilde Johnsen and Bj\orn Naume and Raymond R. Samaha and Anne-Lise B\orresen-Dale},
  journal={BMC Genomics},
  year={2006},
  volume={7},
  pages={127 - 127}
}
Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated as the two main subtypes out of a total of five molecular subtypes of breast cancer. These two are associated with distinctly different gene expression patterns and more importantly, a significant difference in clinical outcome. To further validate and more thoroughly characterize these two subtypes… CONTINUE READING