Distinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyte

@inproceedings{Tissot2017DistinctMC,
  title={Distinct molecular cues ensure a robust microtubule-dependent nuclear positioning in the Drosophila oocyte},
  author={Nicolas Tissot and J. -A. Lepesant and Fred Bernard and Kevin Legent and Floris Bosveld and Charlotte Martin and Orestis Faklaris and Yohanns Bella{\"i}che and Ma{\"i}t{\'e} Coppey and Antoine Guichet},
  booktitle={Nature communications},
  year={2017}
}
Controlling nucleus localization is crucial for a variety of cellular functions. In the Drosophila oocyte, nuclear asymmetric positioning is essential for the reorganization of the microtubule (MT) network that controls the polarized transport of axis determinants. A combination of quantitative three-dimensional live imaging and laser ablation-mediated force analysis reveal that nuclear positioning is ensured with an unexpected level of robustness. We show that the nucleus is pushed to the… CONTINUE READING
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