Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.

@article{Fezza2014DistinctMO,
  title={Distinct modulation of the endocannabinoid system upon kainic acid-induced in vivo seizures and in vitro epileptiform bursting.},
  author={Filomena Fezza and Maria Cristina Marrone and Riccardo Avvisati and Monia di Tommaso and Mirko Lanuti and Cinzia Rapino and Nicola Biagio Mercuri and Mauro Maccarrone and Silvia Marinelli},
  journal={Molecular and cellular neurosciences},
  year={2014},
  volume={62},
  pages={1-9}
}
There is clear evidence on the neuroprotective role of the endocannabinoid (eCB) signaling cascade in various models of epilepsy. In particular, increased levels of eCBs protect against kainic acid (KA)-induced seizures. However, the molecular mechanisms underlying this effect and its age-dependence are still unknown. To clarify this issue, we investigated which step of the biosynthetic and catabolic pathways of the eCBs may be responsible for the eCB-mediated neuroprotection in the hippocampus… CONTINUE READING
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