Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.

@article{He1995DistinctMO,
  title={Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.},
  author={Weiwei He and Thomas J. O'Neill and Thomas A. Gustafson},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 40},
  pages={23258-62}
}
Insulin receptor substrate 1 (IRS-1) and src homology and collagen protein (SHC) are signaling proteins which are rapidly phosphorylated on tyrosines after insulin receptor (IR) activation. We have recently shown that both SHC and IRS-1 interact with the tyrosine-phosphorylated NPEY motif of the IR and insulin-like growth factor I receptor via non-SH2… CONTINUE READING