Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo.

@article{Weissler2015DistinctMO,
  title={Distinct modes of antigen presentation promote the formation, differentiation, and activity of foxp3+ regulatory T cells in vivo.},
  author={Katherine A. Weissler and Victoria M Garcia and Elizabeth Z Kropf and Malinda K. Aitken and Felipe Bedoya and Amaya I. Wolf and Jan Erikson and Andrew J. Caton},
  journal={Journal of immunology},
  year={2015},
  volume={194 8},
  pages={3784-97}
}
How the formation and activity of CD4(+)Foxp3(+) regulatory T cells (Tregs) are shaped by TCR recognition of the diverse array of peptide:MHC complexes that can be generated from self-antigens and/or foreign Ags in vivo remains poorly understood. We show that a self-peptide with low (but not high) stimulatory potency promotes thymic Treg formation and can induce conventional CD4(+) T cells in the periphery to become Tregs that express different levels of the transcription factor Helios… CONTINUE READING