Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.

@article{GarcaMuse2005DistinctMO,
  title={Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.},
  author={Tatiana Garc{\'i}a-Muse and Simon J. Boulton},
  journal={The EMBO journal},
  year={2005},
  volume={24 24},
  pages={4345-55}
}
ATM and ATR are key components of the DNA damage checkpoint. ATR primarily responds to UV damage and replication stress, yet may also function with ATM in the checkpoint response to DNA double-strand breaks (DSBs), although this is less clear. Here, we show that atl-1 (Caenorhabditis elegans ATR) and rad-5/clk-2 prevent mitotic catastrophe, function in the S-phase checkpoint and also cooperate with atm-1 in the checkpoint response to DSBs after ionizing radiation (IR) to induce cell cycle… CONTINUE READING
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