Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity.

@article{Kouvela2009DistinctMO,
  title={Distinct mode of interaction of a novel ketolide antibiotic that displays enhanced antimicrobial activity.},
  author={Ekaterini C. Kouvela and Dimitrios L. Kalpaxis and Daniel N. Wilson and George P Dinos},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 4},
  pages={1411-9}
}
Ketolides represent the latest generation of macrolide antibiotics, displaying improved activities against some erythromycin-resistant strains, while maintaining their activity against erythromycin-susceptible ones. In this study, we present a new ketolide, K-1325, that carries an alkyl-aryl side chain at C-13 of the lactone ring. According to our genetic… CONTINUE READING