Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis

@article{Zella2011DistinctMI,
  title={Distinct microbiome in pouchitis compared to healthy pouches in ulcerative colitis and familial adenomatous polyposis},
  author={Garrett C. Zella and E. Hait and T. Glavan and D. Gevers and D. Ward and C. Kitts and J. Korzenik},
  journal={Inflammatory Bowel Diseases},
  year={2011},
  volume={17},
  pages={1092–1100}
}
BACKGROUND Pouchitis occurs in up to 50% of patients with ulcerative colitis (UC) undergoing ileal pouch anal anastomosis (IPAA. [...] Key Method Patients with active pouchitis were identified using the Pouchitis Disease Activity Index (PDAI). Ileal pouch mucosal biopsies and fecal samples were analyzed with a 16S rDNA-based terminal restriction fragment length polymorphism (TRFLP) approach. Pooled fecal DNA from four UCP and four FAP pouches were sequenced for further speciation. Expand
Comprehensive analysis of the bacterial content of stool from patients with chronic pouchitis, normal pouches, or familial adenomatous polyposis pouches
TLDR
Bacterial groups within the expanded phylogenetic gap of pouch patients may have roles in the pathogenesis of pouchitis. Expand
Relationship between pouch microbiota and pouchitis following restorative proctocolectomy for ulcerative colitis.
TLDR
There is evidence that a dysbiosis characterized by decreased gut microbiota diversity in UC-IPAA patients may, in genetically predisposed subjects, lead to aberrant mucosal immune regulation triggering an inflammatory process. Expand
Characterization of the Gut-Associated Microbiome in Inflammatory Pouch Complications Following Ileal Pouch-Anal Anastomosis
TLDR
Specific genera are associated with inflammation of the ileal pouch, with a reduction of typically ubiquitous organisms characterizing the inflammatory phenotypes. Expand
Fecal microbiota in pouchitis and ulcerative colitis
TLDR
Less diverse fecal microbiota was present in patients with ulcerative colitis and pouchitis, and similar microbiota, such as Clostridium perfringens, were shared in both UCand pouchitis. Expand
The effect of Clostridium butyricum MIYAIRI on the prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis
TLDR
The results suggest that probiotic therapy with CBM achieved favorable results with minimal side effects and might be a useful complementary therapy for the prevention of pouchitis in patients with UC who have undergone IPAA. Expand
Etiology of pouchitis*
TLDR
A detailed review of the data focusing on the pouch microbiota and the immune responses that support this hypothesis is presented, and the contribution of luminal metabolic factors and the epithelial membrane in the etiology of this inflammatory process is discussed. Expand
Inflammatory pouch disease: The spectrum of pouchitis.
TLDR
The spectrum of pouchitis and the specific features related to the diagnosis and treatment of the various forms are presented. Expand
Role of Intestinal Bacteria in the Pathogenesis of Pouchitis
TLDR
Recent studies exploring the pouch microbiota in health and disease, the relationship of bacterial metabolites and pouchitis, and the role of antibiotics and probiotics for the treatment and prevention of pouchitis are summarized. Expand
Exclusive elemental diet impacts on the gastrointestinal microbiota and improves symptoms in patients with chronic pouchitis.
TLDR
Treatment with four weeks elemental diet appeared to improve the symptoms of chronic pouchitis in some patients but is not an effective strategy for inducing remission, and although a potential symptom modifier, elemental diet cannot be recommended for the routine treatment of active pouchitis. Expand
Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease
TLDR
This study quantifies the effects of inflammation, antibiotic use, and biopsy location upon the microbiome and host transcriptome during pouchitis, and suggests that cross-sectional changes in gut epithelial transcription are not a major component of the host-microbiome regulatory interfaceDuring pouchitis. Expand
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