Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b

@article{Rossi2011DistinctMS,
  title={Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b},
  author={Riccardo L. Rossi and Grazisa Rossetti and Lynn Wenandy and Serena Curti and Anna Ripamonti and Raoul Jean Pierre Bonnal and Roberto Sciarretta Birolo and Monica Kiyoto Moro and Maria Cristina Crosti and Paola Gruarin and Stefano Maglie and Francesco Marabita and Debora Mascheroni and Valeria Parente and Mario Angelo Comelli and Emilio Trabucchi and Raffaele De Francesco and Jens Albrecht Ernst Geginat and Sergio Abrignani and Massimiliano Pagani},
  journal={Nature Immunology},
  year={2011},
  volume={12},
  pages={796-803}
}
MicroRNAs are small noncoding RNAs that regulate gene expression post-transcriptionally. Here we applied microRNA profiling to 17 human lymphocyte subsets to identify microRNA signatures that were distinct among various subsets and different from those of mouse lymphocytes. One of the signature microRNAs of naive CD4+ T cells, miR-125b, regulated the expression of genes encoding molecules involved in T cell differentiation, including IFNG, IL2RB, IL10RA and PRDM1. The expression of synthetic… CONTINUE READING
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