Distinct metal-binding configurations in metallothionein.

@article{Nielson1985DistinctMC,
  title={Distinct metal-binding configurations in metallothionein.},
  author={K B Nielson and Curtis L. Atkin and Dennis R Winge},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 9},
  pages={5342-50}
}
In a study of the binding stoichiometry of various metals to rat liver metallothionein, the protein appears to coordinate metals in 2 distinct configurations. Ions of at least 18 different metals were shown to associate with the protein suggesting that there is little specificity in binding. Most metals exhibited saturation binding at 7 mol eq forming M7-metallothionein. These included Bi(III), Cd(II), Co(II), Hg(II), In(III), Ni(II), Pb(II), Sb(III), and Zn(II). Others metals including Os(III… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

Similar Papers

Loading similar papers…