Distinct metal-binding configurations in metallothionein.

  title={Distinct metal-binding configurations in metallothionein.},
  author={K B Nielson and Curtis L. Atkin and Dennis R Winge},
  journal={The Journal of biological chemistry},
  volume={260 9},
In a study of the binding stoichiometry of various metals to rat liver metallothionein, the protein appears to coordinate metals in 2 distinct configurations. Ions of at least 18 different metals were shown to associate with the protein suggesting that there is little specificity in binding. Most metals exhibited saturation binding at 7 mol eq forming M7-metallothionein. These included Bi(III), Cd(II), Co(II), Hg(II), In(III), Ni(II), Pb(II), Sb(III), and Zn(II). Others metals including Os(III… CONTINUE READING

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