Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.

@article{Laplante2013DistinctMA,
  title={Distinct metabolic and vascular effects of dietary triglycerides and cholesterol in atherosclerotic and diabetic mouse models.},
  author={Marc-Andr{\'e} Laplante and Alexandre Charbonneau and Rita Kohen Avramoglu and Patricia Pelletier and Xiangping Fang and H{\'e}l{\`e}ne Bachelard and Seppo Yl{\"a}-Herttuala and Markku Laakso and Jean-pierre Despr{\'e}s and Yves Deshaies and G. J. Sweeney and Patrick J. Mathieu and Andr{\'e} Marette},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2013},
  volume={305 5},
  pages={
          E573-84
        }
}
Cholesterol and triglyceride-rich Western diets are typically associated with an increased occurrence of type 2 diabetes and vascular diseases. This study aimed to assess the relative impact of dietary cholesterol and triglycerides on glucose tolerance, insulin sensitivity, atherosclerotic plaque formation, and endothelial function. C57BL6 wild-type (C57) mice were compared with atherosclerotic LDLr(-/-) ApoB(100/100) (LRKOB100) and atherosclerotic/diabetic IGF-II × LDLr(-/-) ApoB(100/100… CONTINUE READING
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