Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.

@article{Hale2013DistinctMC,
  title={Distinct memory CD4+ T cells with commitment to T follicular helper- and T helper 1-cell lineages are generated after acute viral infection.},
  author={James Scott Hale and Ben Youngblood and Donald R. Latner and Ata Ur Rasheed Mohammed and Lilin Ye and Rama S Akondy and Tuoqi Wu and Smita S Iyer and Rafi Ahmed},
  journal={Immunity},
  year={2013},
  volume={38 4},
  pages={805-17}
}
CD4(+) T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody responses. However, it remains unclear whether there are CD4(+) memory T cells committed to the Tfh cell lineage after antigen clearance. By using adoptive transfer of antigen-specific memory CD4(+) T cell subpopulations in the lymphocytic choriomeningitis virus infection model, we found that there are distinct memory CD4(+) T cell populations… CONTINUE READING
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