Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta.

@article{Frank2003DistinctMO,
  title={Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta.},
  author={Gerald Frank and Mizuo Mifune and Tadashi Inagami and Motoi Ohba and Terukatsu Sasaki and Shigeki Higashiyama and Peter J Dempsey and Satoru Eguchi},
  journal={Molecular and cellular biology},
  year={2003},
  volume={23 5},
  pages={1581-9}
}
Reactive oxygen species (ROS) are implicated in cardiovascular diseases. ROS, such as H2O2, act as second messengers to activate diverse signaling pathways. Although H2O2 activates several tyrosine kinases, including the epidermal growth factor (EGF) receptor, JAK2, and PYK2, in vascular smooth muscle cells (VSMCs), the intracellular mechanism by which ROS activate these tyrosine kinases remains unclear. Here, we identified two distinct signaling pathways required for receptor and nonreceptor… CONTINUE READING
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