Distinct mechanisms of bidirectional activity-dependent synaptic plasticity in superficial and deep layers of rat entorhinal cortex.

@article{Solger2004DistinctMO,
  title={Distinct mechanisms of bidirectional activity-dependent synaptic plasticity in superficial and deep layers of rat entorhinal cortex.},
  author={J{\"o}rg Solger and Christian Wozny and Denise Manahan-Vaughan and Joachim Behr},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 7},
  pages={2003-7}
}
The entorhinal cortex plays a key role in processing memory information in the brain; superficial layers relay information to, and deep layers receive information from, the hippocampus. The cellular mechanisms of memory are thought to include a number that produce long-term potentiation (LTP) and depression (LTD) of synaptic strength. Our work presents evidence that LTP and LTD occur simultaneously at memory-relevant synapses. We report here that low frequency stimulation generates NMDA… CONTINUE READING