Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras.

  title={Distinct mechanisms of alpha 5beta 1 integrin activation by Ha-Ras and R-Ras.},
  author={Tatsuo Kinashi and Kumiko Katagiri and Sumiko Watanabe and Bart Vanhaesebroeck and Julian Downward and Kiyoshi Takatsu},
  journal={The Journal of biological chemistry},
  volume={275 29},
To investigate the possible roles of the Ras/Rho family members in the inside-out signals to activate integrins, we examined the ability of Ras/Rho small GTPases to stimulate avidity of alpha(5)beta(1) (VLA-5) to fibronectin in bone marrow-derived mast cells. We found that both Ha-Ras(Val-12) and R-Ras(Val-38) had strong stimulatory effects on adhesion and ligand binding activity of VLA-5 to fibronectin. However, only Ha-Ras(Val-12)-, but not R-Ras(Val-38)-induced adhesion was inhibited by… CONTINUE READING

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