Corpus ID: 22888382

Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

@article{Tran1997DistinctMF,
  title={Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.},
  author={Hang Tran and Peter Nickerson and Andrea Restifo and Maria A. Ivis-Woodward and Amisha Patel and R D Allen and Terry B. Strom and Peta J. O’Connell},
  journal={Journal of immunology},
  year={1997},
  volume={159 5},
  pages={
          2232-9
        }
}
  • Hang Tran, Peter Nickerson, +5 authors Peta J. O’Connell
  • Published in Journal of immunology 1997
  • Biology, Medicine
  • A murine CTLA4/Fc gamma2a heavy chain (mCTLA4-Fc) chimeric fusion molecule was used in B6AF1 recipients of BALB/c pancreatic islet allografts to study the induction and maintenance of tolerance following inhibition of the CD28-B7 pathway for T cell activation. Donor-specific tolerance was achieved by administering 100 microg of mCTLA4-Fc on alternate days for 14 days (8 total doses) or a single 500 microg dose of mCTLA4-Fc on day 2 after transplant. Tolerance was mediated by long-lived… CONTINUE READING

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