Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI.

@article{Sun2007DistinctMF,
  title={Distinct mechanisms for OxLDL uptake and cellular trafficking by class B scavenger receptors CD36 and SR-BI.},
  author={Bing Sun and Boris B. Boyanovsky and Margery A. Connelly and Preetha Shridas and Deneys R. van der Westhuyzen and Nancy R. Webb},
  journal={Journal of lipid research},
  year={2007},
  volume={48 12},
  pages={2560-70}
}
Modified forms of LDL, including oxidized low density lipoprotein (OxLDL), contribute to macrophage lipid accumulation in the vessel wall. Despite the pathophysiological importance of uptake pathways for OxLDL, the molecular details of OxLDL endocytosis by macrophages are not well understood. Studies in vitro demonstrate that the class B scavenger receptor CD36 mediates macrophage uptake and degradation of OxLDL. Although the closely related scavenger receptor class B type I (SR-BI) binds OxLDL… CONTINUE READING

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