Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1.

@article{Jimnez2001DistinctMC,
  title={Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1.},
  author={Eugenio Jim{\'e}nez and {\'A}ngeles Vicente and Rosa Saced{\'o}n and Juan Jos{\'e} Fern{\'a}ndez Mu{\~n}oz and Gerry Weinmaster and Agust{\'i}n G Zapata and A. Gonzalez Varas},
  journal={Journal of immunology},
  year={2001},
  volume={166 10},
  pages={5898-908}
}
In adult life, the high CD4:CD8 cell ratio observed in peripheral lymphoid organs originates in the thymus. Our results show that the low peripheral CD4:CD8 cell ratio seen during fetal life also has an intrathymic origin. This distinct production of CD4(+)CD8(-) and CD4(-)CD8(+) thymocytes is regulated by the developmental age of the thymic stroma. The differential expression of Notch receptors and their ligands, especially Jagged1, throughout thymus development plays a key role in the… CONTINUE READING

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