Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells.

@article{Maeda2001DistinctMO,
  title={Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells.},
  author={Shin Maeda and Masao Akanuma and Yuzo Mitsuno and Yoshihiro Hirata and Keiji Ogura and Haruhiko Yoshida and Yasushi Shiratori and Masao Omata},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 48},
  pages={44856-64}
}
NF-kappaB is a critical regulator of genes involved in inflammation. Gastric epithelial cells and macrophages are considered the main sources of pro-inflammatory cytokines. We investigated NF-kappaB activation by Helicobacter pylori in MKN45 gastric epithelial cells and THP-1 monocytic cells. Although, cag pathogenicity island (PAI)-positive H. pylori (wild… CONTINUE READING