Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.

  title={Distinct loci in the CHRNA5/CHRNA3/CHRNB4 gene cluster are associated with onset of regular smoking.},
  author={Sarah H. Stephens and Sarah M Hartz and Nicole R. Hoft and Nancy L. Saccone and Robin C Corley and John K Hewitt and Christian Jean Hopfer and Naomi Breslau and Hilary Coon and Xiangning Chen and Francesca Ducci and Nicole D. Dueker and Nora Franceschini and Josef Frank and Younghun Han and Nadia N. Hansel and Chenhui Jiang and Tellervo Korhonen and Penelope A. Lind and Jason R Liu and Leo-Pekka Lyytik{\"a}inen and Martha Michel and John R. Shaffer and Susan E. Short and Juzhong Sun and Alexander Teumer and John R. Thompson and Nicole Vogelzangs and Jacqueline M. Vink and Angela S. Wenzlaff and William Wheeler and Bao-zhu Yang and Steven H. Aggen and Anthony J. Balmforth and Sebastian E. Baumeister and Terri H. Beaty and Daniel J Benjamin and Andrew Bergen and Ulla Broms and David Cesarini and Nilanjan Chatterjee and Jingchun Chen and Y C Cheng and Sven Cichon and David Couper and Francesco Cucca and Danielle M Dick and Tatiana Foroud and Helena F Furberg and Ina Giegling and Nathan A. Gillespie and Fangyi Gu and Alistair Scott Hall and Jenni H{\"a}llfors and Shizhong Han and Annette M Hartmann and Kauko Heikkil{\"a} and Ian B. Hickie and Jouke Jan Hottenga and Pekka J Jousilahti and Marika A. Kaakinen and Mika K{\"a}h{\"o}nen and Philipp D Koellinger and Stephen Kittner and Bettina Konte and Maria-Teresa Landi and Tiina E. Laatikainen and M. Leppert and Steven M. Levy and Rasika A. Mathias and Daniel W McNeil and Sarah E. Medland and Grant W. Montgomery and Tanda Murray and Matthias Nauck and Kari E. North and Peter D. Par{\'e} and Michele L. Pergadia and Ingo Ruczinski and Veikko V Salomaa and Jorma Viikari and Gonneke A H M Willemsen and Kathleen Carole Barnes and Eric Boerwinkle and Dorret I. Boomsma and Neil Caporaso and Howard J. Edenberg and Clyde Francks and Joel Gelernter and Hans J{\"o}rgen Grabe and Hyman Hops and Marjo-Riitta Jarvelin and Magnus Johannesson and Kenneth S. Kendler and Terho Lehtim{\"a}ki and Patrik K. E. Magnusson and Mary L. Marazita and Jonathan Marchini and Braxton D. Mitchell and Markus M. N{\"o}then and Brenda W. J. H. Penninx and Olli Raitakari and Marcella Rietschel and Dan Rujescu and Nilesh J. Samani and Ann Grossbart Schwartz and Sanjay Shete and Margaret Spitz and Gary E. Swan and Henry V{\"o}lzke and Juha Veijola and Qingyi Wei and Chris Amos and Dale S. Cannon and Richard A Grucza and Dorothy M Hatsukami and Andrew Heath and Eric Otto Johnson and Jaakko M Kaprio and Pamela A. F. Madden and Nicholas G. Martin and Victoria L Stevens and Robert B Weiss and Peter Kraft and Laura J. Bierut and Marissa A. Ehringer},
  journal={Genetic epidemiology},
  volume={37 8},
Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. Of the few reports that have focused on early smoking behaviors, association results have been mixed. This meta-analysis examines early smoking phenotypes and SNPs in the gene… CONTINUE READING