Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.

Abstract

Guanine nucleotide exchange factor proteins of the Tiam family are activators of the Rho GTPase Rac1 and critical for cell morphology, adhesion, migration, and polarity. These proteins are modular and contain a variety of interaction domains, including a single post-synaptic density-95/discs large/zonula occludens-1 (PDZ) domain. Previous studies suggest… (More)
DOI: 10.1021/bi1013613

Topics

Cite this paper

@article{Shepherd2011DistinctLS, title={Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.}, author={Tyson Robert Shepherd and Ryan L. Hard and Ann Marie Murray and Dehua Pei and Ernesto J Fuentes}, journal={Biochemistry}, year={2011}, volume={50 8}, pages={1296-308} }