Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.

@article{Paill2010DistinctLO,
  title={Distinct levels of dopamine denervation differentially alter striatal synaptic plasticity and NMDA receptor subunit composition.},
  author={Vincent Paill{\'e} and Barbara Picconi and Vincenza Bagetta and Veronica Ghiglieri and Carmelo Alessio Sgobio and Massimiliano Di Filippo and Maria Teresa Viscomi and Carmela Giamp{\`a} and Francesca R Fusco and Fabrizio Gardoni and Giorgio Bernardi and Paul Greengard and Monica di Luca and Paolo Calabresi},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 42},
  pages={14182-93}
}
A correct interplay between dopamine (DA) and glutamate is essential for corticostriatal synaptic plasticity and motor activity. In an experimental model of Parkinson's disease (PD) obtained in rats, the complete depletion of striatal DA, mimicking advanced stages of the disease, results in the loss of both forms of striatal plasticity: long-term potentiation (LTP) and long-term depression (LTD). However, early PD stages are characterized by an incomplete reduction in striatal DA levels. The… CONTINUE READING
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