Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.

@article{Johenning2002DistinctIC,
  title={Distinct intracellular calcium transients in neurites and somata integrate neuronal signals.},
  author={Friedrich W. Johenning and Michal Zochowski and Stuart J Conway and Andrew Bruce Holmes and Peter Koulen and Barbara E Ehrlich},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 13},
  pages={5344-53}
}
Intracellular calcium signals have distinct temporal and spatial patterns in neurons in which signal initiation and repetitive spiking occurs predominantly in the neurite. We investigated the functional implications of the coexpression of different isoforms of ryanodine receptors (RyR) and inositol 1,4,5-trisphosphate receptors (InsP3Rs) using immunocytochemistry, Western blotting, and calcium imaging in neuronally differentiated PC12 cells. InsP3R type III, an isoform that has been shown to be… CONTINUE READING
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