Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.

@article{Lewis2001DistinctIO,
  title={Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.},
  author={Jim F. Lewis and Lisa Eiben and David L. G. Nelson and Jeffrey I. Cohen and Kim E Nichols and Hans D. Ochs and Luigi D Notarangelo and Colin S. Duckett},
  journal={Clinical immunology},
  year={2001},
  volume={100 1},
  pages={15-23}
}
X-linked lymphoproliferative syndrome (XLP; Duncan's disease) is a primary immunodeficiency disease that manifests as an inability to regulate the immune response to Epstein-Barr virus (EBV) infection. Here we examine the ability of the product of the gene defective in XLP, SAP (DSHP/SH2D1A), to associate with the cytoplasmic domains of several members of the CD2 subfamily of cell surface receptors, including SLAM, 2B4, and CD84. While recruitment of SAP to SLAM occurred in a phosphorylation… CONTINUE READING

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