Distinct interaction of versican/PG-M with hyaluronan and link protein.

  title={Distinct interaction of versican/PG-M with hyaluronan and link protein.},
  author={Kazu Matsumoto and Masafumi Shionyu and Mitiko Gō and Katsuji Shimizu and Tamayuki Shinomura and Koji Kimata and Hideto Watanabe},
  journal={The Journal of biological chemistry},
  volume={278 42},
The proteoglycan aggregate is the major structural component of the cartilage matrix, comprising hyaluronan (HA), link protein (LP), and a large chondroitin sulfate (CS) proteoglycan, aggrecan. Here, we found that another member of aggrecan family, versican, biochemically binds to both HA and LP. Functional analyses of recombinant looped domains (subdomains) A, B, and B' of the N-terminal G1 domain revealed that the B-B' segment of versican is adequate for binding to HA and LP, whereas A and B… CONTINUE READING

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