Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.

@article{Odobasic2008DistinctIV,
  title={Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis.},
  author={Dragana Odobasic and Michelle Leech and Jin Rong Xue and Stephen Roger Holdsworth},
  journal={Immunology},
  year={2008},
  volume={124 4},
  pages={
          503-13
        }
}
  • Dragana Odobasic, Michelle Leech, +1 author Stephen Roger Holdsworth
  • Published in Immunology 2008
  • Biology, Medicine
  • CD80 and CD86 play a critical role in the initiation of T-cell responses. However, their role in the in vivo effector CD4+ T-cell responses has been less extensively investigated. The current studies have examined the functional relevance of CD80 and CD86 in the effector CD4+ T-cell responses inducing antigen-induced arthritis. Arthritis was induced in C57BL/6 mice by sensitization to methylated bovine serum albumin (mBSA) on day 0, booster immunization (day 7) and intra-articular injection of… CONTINUE READING

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