Distinct impact of vitamin D insufficiency on calcitriol levels in chronic renal failure and renal transplant patients: a role for FGF23.

@article{Mazzaferro2012DistinctIO,
  title={Distinct impact of vitamin D insufficiency on calcitriol levels in chronic renal failure and renal transplant patients: a role for FGF23.},
  author={Sandro Mazzaferro and Marzia Pasquali and Francesco Pugliese and Franco Citterio and Antonio Gargiulo and Silverio Rotondi and Lida Tartaglione and Carmina Conte and Giuliana Pirr{\`o} and Franco Taggi},
  journal={Journal of nephrology},
  year={2012},
  volume={25 6},
  pages={
          1108-18
        }
}
INTRODUCTION Vitamin D insufficiency contributes to calcitriol (1,25D) reduction in chronic kidney disease (CKD). Since CKD patients on conservative therapy (CRF) mostly develop, whereas transplant (TX) patients possibly recover from, secondary hyperparathyroidism (SH), we hypothesized a different efficiency of vitamin D hydroxylation in these 2 clinical conditions. METHODS We compared the impact of reduced 25-hydroxyvitamin D (25D) on circulating 1,25D in 111 CRF (mean age 63 ± 15 years… CONTINUE READING
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