Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.

@article{Nesbitt2002DistinctGI,
  title={Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.},
  author={Warwick S. Nesbitt and Suhasini Kulkarni and S. Giuliano and Isaac Goncalves and Sacha M. Dopheide and Cindy L Yap and Ian S. Harper and Hatem H. Salem and Shaun P Jackson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 4},
  pages={2965-72}
}
We have investigated the calcium signaling relationship between the two major platelet adhesion receptors, glycoprotein Ib/V/IX (GPIb/V/IX) and integrin alpha(IIb)beta(3), involved in regulating platelet adhesion on von Willebrand factor (vWf) under flow. Our studies demonstrate that GPIb engagement of immobilized vWf elicits a transient calcium spike that may function to promote reversible arrest of translocating platelets. Subsequent integrin alpha(IIb)beta(3) engagement of vWf promotes… CONTINUE READING

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