Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome.

@article{Eisenhofer2004DistinctGE,
  title={Distinct gene expression profiles in norepinephrine- and epinephrine-producing hereditary and sporadic pheochromocytomas: activation of hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome.},
  author={Graeme Eisenhofer and T T Huynh and Karel Pacak and Frederieke M. Brouwers and M. M. Walther and W. Marston Linehan and Peter J. Munson and Massimo Mannelli and David S Goldstein and Abdel G. Elkahloun},
  journal={Endocrine-related cancer},
  year={2004},
  volume={11 4},
  pages={897-911}
}
Pheochromocytomas in von Hippel-Lindau (VHL) syndrome produce exclusively norepinephrine, whereas those in multiple endocrine neoplasia type 2 (MEN 2) produce epinephrine. This study examined the pathways activated in VHL-associated pheochromocytomas by comparing gene expression profiles in VHL and MEN 2 tumors in relationship to profiles in sporadic norepinephrine- and epinephrine-producing tumors. Larger and more distinct differences in gene expression among hereditary than sporadic tumors… CONTINUE READING