Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs

@article{Shen2004DistinctGE,
  title={Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs},
  author={Yulei Shen and Javeed Iqbal and Li Xiao and Ryan C Lynch and Andreas Rosenwald and Louis M. Staudt and Simon A Sherman and Karen Dybkaer and Guimei Zhou and James D. Eudy and Jan Delabie and T. Mckeithan and Wing Chung Chan},
  journal={BMC Immunology},
  year={2004},
  volume={5},
  pages={20 - 20}
}
There are three major B-cell compartments in peripheral lymphoid organs: the germinal center (GC), the mantle zone (MNZ) and the marginal zone (MGZ). Unique sets of B-cells reside in these compartments, and they have specific functional roles in humoral immune response. MNZ B cells are naïve cells in a quiescent state and may participate in GC reactions upon proper stimulation. The adult splenic MGZ contains mostly memory B cells and is also known to provide a rapid response to particulate… CONTINUE READING