Distinct functions of vascular endothelial and smooth muscle PPARgamma in regulation of blood pressure and vascular tone.

@article{Wang2009DistinctFO,
  title={Distinct functions of vascular endothelial and smooth muscle PPARgamma in regulation of blood pressure and vascular tone.},
  author={Ningning Wang and J. David Symons and Hui Zhang and Zhanjun Jia and Frank J. Gonzalez and Tianxin Yang},
  journal={Toxicologic pathology},
  year={2009},
  volume={37 1},
  pages={21-7}
}
Thiazolidinediones (TZDs) are peroxisome proliferators-activated receptor gamma (PPARgamma) activators that exhibit antihypertensive and vasculo-protective effects. Here we describe the use of Tie2Cre/flox and SM22Cre/flox mice, which respectively lacked PPARgamma in the endothelium and the smooth muscle, to study vascular function of PPARgamma… CONTINUE READING