Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene.

@article{Fu2001DistinctFO,
  title={Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene.},
  author={Sidney W. Fu and Holly S Stevenson and Jeffrey W Strovel and Susanne B Haga and Judith Stamberg and Kyung Soon Do and Patricia E. Berg},
  journal={Gene},
  year={2001},
  volume={278 1-2},
  pages={
          131-9
        }
}
Homeotic proteins are transcription factors that regulate the expression of multiple genes involved in development and differentiation. We previously isolated a cDNA encoding such a protein from the human leukemia cell line K562, termed Beta Protein 1 (BP1), which is involved in negative regulation of the human beta-globin gene. Sequence comparison revealed that BP1 is a member of the distal-less (DLX) family of homeobox genes and that it shares its homeodomain and 3' sequences with another DLX… CONTINUE READING
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