Distinct functions of the two isoforms of dopamine D2 receptors

@article{Usiello2000DistinctFO,
  title={Distinct functions of the two isoforms of dopamine D2 receptors},
  author={A. Usiello and J. Baik and F. Roug{\'e}-Pont and R. Picetti and A. Di{\'e}rich and M. Lemeur and P. Piazza and E. Borrelli},
  journal={Nature},
  year={2000},
  volume={408},
  pages={199-203}
}
  • A. Usiello, J. Baik, +5 authors E. Borrelli
  • Published 2000
  • Biology, Medicine
  • Nature
  • Signalling through dopamine D2 receptors governs physiological functions related to locomotion, hormone production and drug abuse. D2 receptors are also known targets of antipsychotic drugs that are used to treat neuropsychiatric disorders such as schizophrenia. By a mechanism of alternative splicing, the D2 receptor gene encodes two molecularly distinct isoforms, D2S and D2L, previously thought to have the same function. Here we show that these receptors have distinct functions in vivo; D2L… CONTINUE READING
    649 Citations
    Dopamine D2L receptor-interacting proteins regulate dopaminergic signaling.
    • N. Shioda
    • Biology, Medicine
    • Journal of pharmacological sciences
    • 2017
    • 5
    Distinct roles of dopamine D2L and D2S receptor isoforms in the regulation of protein phosphorylation at presynaptic and postsynaptic sites
    • 186
    • PDF
    Dopamine D2 Receptor-Mediated Inhibition of Dopaminergic Neurons in Mice Lacking D2L Receptors
    • 83
    • PDF
    Antagonism of dopamine D2 receptor/β-arrestin 2 interaction is a common property of clinically effective antipsychotics
    • 275
    • PDF
    Brain dopamine receptors--research perspectives and potential sites of regulation.
    • 21
    • PDF
    Differential regulation of striatal motor behavior and related cellular responses by dopamine D2L and D2S isoforms
    • 18
    • Highly Influenced
    • PDF
    Voltage sensitivity of dopamine D2-like receptors

    References

    SHOWING 1-10 OF 97 REFERENCES
    Dopamine D2 receptors in signal transduction and behavior.
    • 124
    Prominence of the dopamine D2 short isoform in dopaminergic pathways.
    • 258
    • PDF
    Preferential coupling between dopamine D2 receptors and G-proteins.
    • 127
    • PDF
    Dopamine receptors: molecular biology, biochemistry and behavioural aspects.
    • 473