Distinct functions of the two isoforms of dopamine D2 receptors

  title={Distinct functions of the two isoforms of dopamine D2 receptors},
  author={A. Usiello and J. Baik and F. Roug{\'e}-Pont and R. Picetti and A. Di{\'e}rich and M. Lemeur and P. Piazza and E. Borrelli},
  • A. Usiello, J. Baik, +5 authors E. Borrelli
  • Published 2000
  • Biology, Medicine
  • Nature
  • Signalling through dopamine D2 receptors governs physiological functions related to locomotion, hormone production and drug abuse. D2 receptors are also known targets of antipsychotic drugs that are used to treat neuropsychiatric disorders such as schizophrenia. By a mechanism of alternative splicing, the D2 receptor gene encodes two molecularly distinct isoforms, D2S and D2L, previously thought to have the same function. Here we show that these receptors have distinct functions in vivo; D2L… CONTINUE READING
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