Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates

@inproceedings{Lee2015DistinctFO,
  title={Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates},
  author={Heeseung Lee and M R Ko},
  booktitle={Scientific reports},
  year={2015}
}
How neuropeptides in the primate spinal cord regulate itch and pain is largely unknown. Here we elucidate the sensory functions of spinal opioid-related peptides and gastrin-releasing peptide (GRP) in awake, behaving monkeys. Following intrathecal administration, β-endorphin (10-100 nmol) and GRP (1-10 nmol) dose-dependently elicit the same degree of robust itch scratching, which can be inhibited by mu-opioid peptide (MOP) receptor and GRP receptor (BB2) antagonists, respectively. Unlike… CONTINUE READING

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The anti - itch effects of dynorphin A can be reversed by a kappa - opioid peptide ( KOP ) receptor antagonist nor - binaltorphimine .
The anti - itch effects of dynorphin A can be reversed by a kappa - opioid peptide ( KOP ) receptor antagonist nor - binaltorphimine .
PainNo subtypePruritus
In contrast , enkephalins ( 100 - 1000 nmol ) and nociceptin - orphanin FQ ( 3 - 30 nmol ) only inhibit pain without eliciting itch .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
How neuropeptides in the primate spinal cord regulate itch and pain is largely unknown .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
These nonhuman primate behavioral models with spinal delivery of ligands advance our understanding of distinct functions of neuropeptides for modulating itch and pain .
Distinct functions of opioid - related peptides and gastrin - releasing peptide in regulating itch and pain in the spinal cord of primates .
PruritusNo subtypePain
How neuropeptides in the primate spinal cord regulate itch and pain is largely unknown .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Unlike β-endorphin , which produces itch and attenuates inflammatory pain , GRP only elicits itch without affecting pain .
Distinct functions of opioid - related peptides and gastrin - releasing peptide in regulating itch and pain in the spinal cord of primates .
These nonhuman primate behavioral models with spinal delivery of ligands advance our understanding of distinct functions of neuropeptides for modulating itch and pain .
In contrast , enkephalins ( 100 - 1000 nmol ) and nociceptin - orphanin FQ ( 3 - 30 nmol ) only inhibit pain without eliciting itch .
The anti - itch effects of dynorphin A can be reversed by a kappa - opioid peptide ( KOP ) receptor antagonist nor - binaltorphimine .
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